An investigation into pharmaceutically relevant mutagenicity data and the influence on Ames predictive potential
نویسندگان
چکیده
منابع مشابه
An investigation into pharmaceutically relevant mutagenicity data and the influence on Ames predictive potential
BACKGROUND In drug discovery, a positive Ames test for bacterial mutation presents a significant hurdle to advancing a drug to clinical trials. In a previous paper, we discussed success in predicting the genotoxicity of reagent-sized aryl-amines (ArNH2), a structure frequently found in marketed drugs and in drug discovery, using quantum mechanics calculations of the energy required to generate ...
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Nonparametric regression analysis of data from the Ames mutagenicity assay.
The Ames assay has received widespread attention from statisticians because of its popularity and importance to risk assessment. However, investigators have yet to routinely apply modern regression methods that have been available for more than a decade. We study yet another approach, the application of nonparametric regression techniques, not as the ultimate solution but rather as a framework ...
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ژورنال
عنوان ژورنال: Journal of Cheminformatics
سال: 2011
ISSN: 1758-2946
DOI: 10.1186/1758-2946-3-51